. 2021 Aug 2;11:15660. doi: 10.1038/s41598-021-95141-0

Table 1.

Baseline characteristics of studies included in the systematic review and meta-analysis for the relationship between serum Lp (a) levels and risk of ischemic stroke.

S. no.	Author name and year	Ethnicity	Study design	Source of control	Sample size (IS/control)	IS age (mean ± SD)	Control age (mean ± SD)	Matching criteria	LPA assay method	LPA cut off value	LPA timepoint	Follow up duration	NOS quality score
1.	Shintani et al., 1993³³	Asian	Case–control study	HB	54/81	62 ± 8.1	61.1 ± 8.6	NA	ELISA	≥ 42.6 mg/dl	4 weeks	NA	5
2.	More et al., 2017³⁴	Asian	Case–control study	HB	100/50	NA	NA	NA	NA	≥ 30 mg/dl	NA	NA	4
3.	Albala et al., 2010³⁵	Caucasian	Case–control study	PB	317/413	69.7 ± 12.3	69.7 ± 11.7	Age, sex and race/ethnicity	Immunonephelometric procedure	≤ 30 mg/dl	Within 72 h	NA	6
4.	Kiechl et al., 2007³⁶	Caucasian	Prospective cohort study	PB	82/683	70.2 ± 10.3	61.8 ± 10.9	Age and sex	ELISA	≥ 24 mg/dl	NA		7
5.	Christopher et al., 1996³⁷	Asian	Case–control study	HB	50/50	27 ± 5	27 ± 5	Age, sex and socioeconomic status	ELISA	NA	NA	NA	5
6.	Fu et al., 2020³⁸	Asian	Case–control study	HB	1953/1953	62.3 ± 11.8	59.9 ± 11.1	Age and sex	Latex agglutination turbidimetric method	23.2 mg/dl	NA	NA	7
7.	Dhamija et al., 2009³⁹	Asian	Case–control study	HB	66/72	54.43 ± 13	54.4 ± 13	Age and sex	Immunoturbidimetric immunoassay	≤ 30 mg/dl	Within 12 h	NA	6
8.	Shao-yi-Li et al., 2014⁴⁰	Asian	Prospective cohort study	PB	181/120	63 ± 4.6	62.5 ± 5.7	Age and sex	Immunoprecipitation techniques	≥ 30 mg/dl	Within 24 h	NA	7
9.	Milionis et al., 2005⁴¹	Caucasian	Case–control study	PB	163/166	77.6 ± 4.8	77.7 ± 4.8	Age and sex	Immunoprecipitation techniques	≥ 30 mg/dl	Within 24 h	No	7
10.	Peng et al., 1999⁴²	Asian	Case–control study	HB	90/90	62.6 ± 8.9	63.1 ± 8.3	NA	ELISA	NA	Within 24 h	No	4
11.	Jurgens et al., 1995⁴³	Caucasian	Case–control study	HB	42/288	51.4 ± 7.2	51 ± 7.1	NA	ELISA	20 mg/dl	Within 48 h	NA	7
12.	Ridker et al., 1995²⁰	Caucasian	Nested case–control study	PB	198/198	62.5 ± 5	62.1 ± 5	Age, sex and smoking	NA	19.68 mg/dl	NA		7
13.	Rigal et al., 2006⁴⁴	Caucasian	Case–control study	PB	100/100	45.3 ± 7.7	45.1 ± 6.8	Age and sex	Immunoturbidimetric method	30 mg/dl	Within 4 days	NA	6
14.	Sun et al., 2003⁴⁵	Asian	Case–control study	PB	1326/1817	61.1 ± 9.2	59.6 ± 8.5	NA	ELISA	NA	Within 6 weeks	NA	7
15.	Tascilar et al., 2008⁴⁶	Caucasian	Case–control study	PB	85/77	61.6 ± 13.5	54.7 ± 8.4	NA	Latex agglutination assay	NA	NA	NA	5
16.	Zenker et al., 1986⁴⁷	Caucasian	Case–control study	HB	46/37	53.6 ± 9.7	54.4 ± 7.7	NA	Electro immunoassay	NA	NA	NA	4
17.	Botet et al., 1992⁴⁸	Caucasian	Case–control study	HB	100/100	64.4 ± 6	64.4 ± 6	Age	Electro immunoassay	NA	NA	NA	4
18.	Glader et al., 1999²¹	Caucasian	Case–control study	PB	101/201	55.6 ± 6.9	55.6 ± 6.8	Age and sex	ELISA	30 mg/dl	NA	NA	4
19.	Poitrine et al., 2010⁴⁹	Caucasian	Prospective cohort study	PB	98/8978	55.6 ± 3	54.8 ± 2.8	NA	Selective bi-site immunoenzymatic assay	NA	Within 12 h		7
20.	Albucher et al., 2000⁵⁰	Caucasian	Case–control study	PB	94/111	35.8 ± 8.2	35.8 ± 8.2	Age	Rocket immunoelectrodiffusion	NA	NA	NA	5
21.	Markus et al., 1997⁵¹	Caucasian	Case–control study	HB	164/91	66.1 ± 9.8	64.6 ± 8.2	NA	ELISA	40 mg/dl	NA	NA	6
22.	Alfthan et al., 1994⁵²	Caucasian	Prospective cohort study	PB	74/269	54 ± 4	54 ± 4	NA	Two-site immunoradiometric method	NA	NA		5
23.	Chakraborty et al., 2013⁵³	Asian	Case–control study	HB	100/120	54 ± 10.9	52.5 ± 9.8	Age and sex	Immunoturbidimetric method	NA	At 1, 7 days, 3 and 6 months		6
24.	Jones et al., 2007⁵⁴	Caucasian	Case–control study	PB	184/230	71.9 ± 10	70.3 ± 6.9	NA	ELISA	> 45 nmol/L	NA	NA	7
25.	Jones et al., 2009⁵⁵	Caucasian	Case–control study	PB	245/439	71.4 ± 10.5	68.8 ± 6.6	NA	ELISA	NA	NA	NA	6
26.	Denti et al., 2003⁵⁶	Caucasian	Case–control study	HB	79/98	82.9 ± 7.4	82.9 ± 7.4	Age and sex	ELISA	NA	Within 48 h	NA	5
27.	Hiraga et al., 1996⁵⁷	Asian	Case–control study	HB	83/39	67.6 ± 10.5	65.3 ± 6.8	NA	Latex immunosorbent assay	NA	NA	NA	4
28.	Pena-Diaz et l., 2003⁵⁸	Caucasian	Case–control study	HB	52/91	53.4 ± 10.5	40.2 ± 13.1	NA	Immunonephelometric method	> 22.45 mg/dl	NA	NA	4
29.	Karttunen et al., 2002⁵⁹	Caucasian	Case–control study	PB	46/104	41.5 ± 3.1	43.7 ± 3.2	NA	ELISA	NA	NA	NA	5
30.	Kario et al., 1994⁶⁰	Asian	Case–control study	PB	31/50	83 ± 5	84 ± 5	NA	ELISA	> 30 mg/dl	Within 4 days	NA	4
31.	Ma Lijuan et al., 2013⁶¹	Asian	Case–control study	HB	124/64	60.6 ± 12.1	62 ± 9.1	NA	Sandwich ELISA	NA	Within 12 h	NA	6
32.	Murai et al.,, 1985⁶²	Asian	Case–control study	HB	156/99	64.8 ± 9	61.5 ± 13.4	Age	Single radial immunodiffusion method	17 mg/dl	NA	NA	4
33.	Lindgren A et al., 1992⁶³	Caucasian	Case–control study	PB	119/159	70.7 ± 9.1	60 ± 11.5	Age	Radioimmunoassay	NA	NA	NA	5
34.	Kooten et al., 1996⁶⁴	Caucasian	Case–control study	HB	119/274	66.3 ± 15.4	50.2 ± 7.4	NA	Two-site immunoradiometric assay	NA	NA	NA	6
35.	Peynet et al., 1999⁶⁵	Caucasian	Case–control study	PB	90/84	37.4 ± 8.7	37.4 ± 8.7	Age and sex	Immunonephelometric assay	NA	After 3 months of stroke	NA	6
36.	Petersen et al., 2007⁶⁶	Caucasian	Case–control study	HB	253/63	63 ± 14	60.2 ± 10.6	Age and sex	Double-antibody ELISA	30 mg/dl	NA	NA	6
37.	Saito et al., 1997⁶⁷	Asian	Case–control study	HB	118/95	71 ± 10		NA	Sandwich ELISA	NA	NA	NA	4
38.	Santos-silva et al., 2002⁶⁸	Caucasian	Case–control study	HB	50/29	20–79		Age	Electro immunodiffusion	NA	NA	NA	4
39.	Seki et al., 1997⁶⁹	Asian	Case–control study	HB	64/37	72.1 ± 8.4	61 ± 20	NA	ELISA	NA	NA	NA	5
40.	Schreiner et al., 1994 (Black)⁷⁰	Caucasian	Prospective cohort study	PB	324/14,818	56.6 ± 6	53 ± 6	NA	ELISA	30 mg/dl	NA	NA	5
41.	Zhang et al., 2013⁷¹	Asian	Case–control study	HB	153/100	63 ± 12.7	63 ± 12.7	Age and sex	Immunoturbidimetric method	NA	NA	NA	6