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. 2021 Aug 2;11:15629. doi: 10.1038/s41598-021-95082-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Enriched biological functions in the core urinary EV proteome. (a) Gene ontology (GO) term cellular component (CC) analysis of the core urinary EV proteome. Barplots show top 5 GO:CC terms associated with the core urinary EV proteome, analyzed using ClueGO²⁸. (b) Gene ontology (GO) term biological process (BP) analysis of the core urinary EV proteome. Barplots show top 5 GO:BP terms associated with the core urinary EV proteome, analyzed using ClueGO²⁸. (c) Schematic overview of the enriched biological functions in the core urinary EV protein network (516 proteins), analyzed by clusterONE³¹ and BINGO³². For the detailed network, see Supplementary Fig. 4. (d) Protein interaction network of EV markers and associated signaling and localization protein clusters, predicted by clusterONE³¹. (e) Protein interaction network of metabolic cluster. Enriched sub-networks predicted by clusterONE³¹ are indicated within the figure. PPP: Pentose-Phosphate Pathway.