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. 2021 Aug 2;12:4664. doi: 10.1038/s41467-021-25015-6

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© The Author(s) 2021, corrected publication 2021

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Fig. 10 — During SARS-CoV-2 infection, the nucleocapsid protein (N) could directly interact with NLRP3 to promote the assembly and activation of NLRP3 inflammasome, thus leading to the production of a large number of inflammatory factors (such as IL-1β, IL-6, TNF, CCL2, and CCL8) and the occurrence of lung injury in mice.