Table 2.
Primary and secondary endpoints.
| Intervention, N (%) | Control, N (%) | Absolute difference (%) | HR (95% CI) | p value | |
|---|---|---|---|---|---|
| Primary endpoint | |||||
| Cardiovascular death, MI, stroke, or cardiac revascularisation* | 214 (22.7) | 256 (27.1) | − 4.4 | 0.81 (0.68–0.97) | 0.02 |
| Cardiovascular death | 64 (29.9) | 62 (24.2) | |||
| MI (non-fatal) | 38 (17.8) | 54 (21.1) | |||
| Stroke (non-fatal) | 65 (30.4) | 84 (32.8) | |||
| Cardiac revascularisation | 47 (22.0) | 56 (21.9) | |||
| Secondary endpoints | |||||
| All-cause mortality | 211 (22.4) | 220 (23.3) | − 0.9 | 0.94 (0.78–1.14) | 0.54 |
| Cardiovascular death | 88 (9.3) | 105 (11.1) | − 1.8 | 0.82 (0.62–1.09) | 0.18 |
| Myocardial infarction | 57 (6.0) | 73 (7.7) | − 1.7 | 0.77 (0.54–1.08) | 0.13 |
| STEMI | 16 (28.1) | 11 (15.1) | |||
| NSTEMI | 41 (71.9) | 62 (84.9) | |||
| Fatal within 30 days | 10 (17.5) | 10 (13.7) | |||
| Cardiac revascularisation | 70 (7.4) | 79 (8.4) | − 1.0 | 0.87 (0.63–1.20) | 0.40 |
| PCI | 56 (80.0) | 61 (77.2) | |||
| CABG | 14 (20.0) | 18 (22.8) | |||
| Stroke | 78 (8.3) | 101 (10.7) | − 2.4 | 0.76 (0.56–1.02) | 0.07 |
| Ischaemic | 74 (94.9) | 87 (86.1) | |||
| Haemorrhagic | 3 (3.8) | 12 (11.9) | |||
| Undefined | 1 (1.3) | 2 (2.0) | |||
| Fatal within 30 days | 11 (14.1) | 12 (11.9) | |||
| TIA | 31 (3.3) | 36 (3.8) | − 0.5 | 0.85 (0.53–1.37) | 0.50 |
The primary endpoint components, subtypes of the secondary endpoints, and fatality are presented as proportions (%) of the main outcome event for each group. MI, Myocardial infarction; STEMI, ST elevation myocardial infarction; NSTEMI, Non-ST elevation myocardial infarction; PCI, Percutaneous coronary intervention; CABG, Coronary artery bypass grafting; TIA, Transient ischemic attack.
*The first event to occur was counted.