TABLE 8.
List of HPV positive Head and neck cancer cell lines developed and described with their key characteristics.
| Cell lines | Anatomical site | HPV type | Key characteristics | Copy number | Developed by | References |
|---|---|---|---|---|---|---|
| 93-VU-147T | Oral cavity | HPV16 | Three integrated sites | NA | VU University Medical Center, Amsterdam Netherlands | Steenbergen et al. (1995) |
| E1-17q21 | ||||||
| E2-5p15.33 (promoter of TERT gene) | ||||||
| L2-3p21 (Intergenic) | ||||||
| UD-SCC-2 | Hypopharynx | HPV16 | Two integrated sites | 14—23 copies | University of Dusseldorf, Dusseldorf, Germany | Ballo et al. (1999) |
| E1-17q12 (Intergenic) | ||||||
| E2-1p32.3 (Intron 14 of JAK1 gene) | ||||||
| UPCI-SCC-90(SCC90) | Tongue | HPV16 | Two integrated sites | 100—500 copies | University of Pittsburgh, Pittsburgh PA | White et al. (2007) |
| E1-12p13 (Intron 1 of ETV gene) | ||||||
| E1-9q31.1 (Intergenic) | ||||||
| UPCI-SCC-154 | Tongue | HPV16 | Four integrated sites | NA | University of Pittsburgh, Pittsburgh PA | White et al. (2007) |
| E1-21p11.1 (Intergenic) | ||||||
| E1-11q22-23 (Intron 3 of PGR gene) | ||||||
| E2-2q33.2 (exon 14 of TMEM237 gene) | ||||||
| E2-7q36 (Intron 3 of PTPRN2 gene) | ||||||
| UPCI-SCC-152 | Hypopharynx | HPV16 | Four integrated sites | NA | University of Pittsburgh, Pittsburgh PA | White et al. (2007) |
| E1-9q31.1 (Intergenic) | ||||||
| E1-12p13 (Intron 1 of ETV gene) | ||||||
| E2-9q22.33 (Intergenic) | ||||||
| LCR-3q23 (Intron 36 of ATR gene) | ||||||
| UM-SCC-47 | Oral cavity/Tongue | HPV16 | Two integrated sites | 21—47 copies | University of Michigan, Ann Arbor, MI | Brenner et al. (2010) |
| E2-3q28 (Intron 10 of TP63 gene) | ||||||
| E2-3q28 (exon 14 of TP63 gene) | ||||||
| HB-2 | Oral mucosa | HPV16 | NA | NA | Tong University, Shanghai, China | Ye et al. (2011) |
| UM-SCC104 | Oral cavity | HPV16 | Three integrated sites | NA | University of Michigan, Ann Arbor, MI | Tang et al. (2012) |
| E1-18q21.3 (Intron 1 of DCC gene) | ||||||
| E2-17q22 (Intergenic) | ||||||
| E2-17p11.2 (Intergenic) | ||||||
| UM-SCC-105 | Larynx | HPV18 | Two integrated sites | NA | University of Michigan, Ann Arbor, MIs | Owen et al. (2016) |
| L1-8q12.3/4p15.33 (Intergenic) | ||||||
| L1-17q12 (Intergenic) | ||||||
| HMS001 | Oral cavity | HPV16 | NA | NA | NA | Kalu et al. (2017) |
| UT-SCC-45 | Floor of the mouth | HPV33 | NA | NA | University of Turku, SF-20520 Turku, Finland | Kalu et al. (2017) |
Abbreviation: NA, not available.