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. 2021 Jul 22;28(8):2305–2314. doi: 10.1038/s41418-021-00834-8

Fig. 2. LTβR signaling controls the homing of LPC and the egress of mature thymocytes.

Fig. 2

A LTβR expression in endothelial cells is required for the homing of lymphoid progenitor cells (LPC) into the thymus by regulating Ccl19, Ccl21, Icam1, and Vcam1 expression. LTα1β2-delivered by SP thymocytes also controls the development and homeostasis of thymic portal endothelial cells (TPEC). B LTβR expression in endothelial cells is required for the thymic egress of mature SP thymocytes by driving their entry into the perivascular space (PVS).