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. 2021 Aug 2;12(8):760. doi: 10.1038/s41419-021-03985-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A APOL1 mRNA expression in different cancers. B APOL1 expression in 77 pairs of tumor tissues and adjacent normal tissues. C Prognostic analysis of APOL1 using survival data of 51 patients from our center. D APOL1 expression in patients divided by cancer stages using expression data from our center (n = 77). E APOL1 expression in patients divided by cancer stages using expression data from TCGA (n = 179). F IHC staining scores of APOL1 expression in 25 paired PC samples. Representative images of different APOL1 expression levels are shown in the left panel. Magnification: ×200. G GSEA results were plotted to visualize the correlation between the expression of APOL1 and dysregulated genes in PC. H APOL1 and NOTCH1-IC expression in PC cell lines (Aspc-1, Bxpc-3, CFPAC-1, MIA PaCa-2, PANC-1, and PATU-8988) compared with that in the normal pancreatic ductal epithelial cell line HPNE detected by qRT-PCR and western blotting. *P < 0.05; ***P < 0.001.