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. 2021 Mar 19;28(8):2450–2464. doi: 10.1038/s41418-021-00762-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The effect of SNORD50A/B knockdown on the proliferation of the indicated cells was assessed by MTT assay. b The effect of SNORD50A/B knockdown on colony formation ability of the indicated cells. Shown are representative images of colony formation. c The effects of SNORD50A/B knockdown on migration and invasion potential of the indicated cells were evaluated by Transwell assays. Shown are representative images of migrating/invading cells. d The effect of SNORD50A/B knockdown on cell cycle distributions in the indicated cells. e The effect of SNORD50A/B knockdown on the apoptosis of the indicated cells. f Representative images of the indicated xenograft tumors and statistical analysis of tumor weight. g The levels of Ki-67 proteins in the indicated xenograft tumors by IHC assay (upper panels). Statistical analysis of the percentage of Ki-67 positive cells was shown in lower panels. Data were presented as mean ± SD. Scale bars, 200 µm. NC, negative control; 50 A/B, SNORD50A/B; *, P < 0.05; **, P < 0.01; ***, P < 0.001.