Table 1.
Demographics and follow-up data.
| Data | Total | Missinga | TD | U | PIGD | MMP | IM | DM |
|---|---|---|---|---|---|---|---|---|
| Number of patients (n) | 89 | n/r | 16 | 14 | 59 | 35 | 33 | 21 |
| Age of onset (yrs) | 59.7 ± 9.2 | 0 | 57.7 ± 8.9 | 58.7 ± 10.3 | 60.4 ± 9.1 | 58.8 ± 10.0 | 59.1 ± 9.1 | 62.1 ± 7.7 |
| Men (n) | 54 (60.7%) | 0 | 8 (50.0%) | 8 (57.1%) | 38 (64.4%) | 19 (54.3%) | 22 (66.7%) | 13 (61.9%) |
| Duration at baseline | 7.9 ± 5.3 | 0 | 6.7 ± 3.9 | 8.0 ± 5.8 | 8.2 ± 5.5 | 6.1 ± 4.0 | 7.4 ± 5.4 | 11.7 ± 5.2 |
| Age at baseline (yrs) | 67.6 ± 9.1 | 0 | 64.4 ± 8.9 | 66.8 ± 8.3 | 68.6 ± 9.2 | 64.9 ± 9.4 | 66.5 ± 8.2 | 73.8 ± 7.0 |
| RBD at baseline (n) | 33 (41.3%) | 9 (10.1%) | 4 (26.7%) | 6 (50.0%) | 23 (43.4%) | 0 | 23 (76.7%) | 10 (55.6%) |
| Hallucinations at baseline | 28 (31.5%) | 0 | 1 (6.3%) | 5 (35.7%) | 22 (37.3%) | 0 | 11 (33.3%) | 17 (81.0%) |
| NMSQ score at baseline | 9.8 ± 4.9 | 7 (7.9%) | 7.5 ± 3.4 | 10.3 ± 5.3 | 10.3 ± 5.0 | 6.4 ± 3.5 | 10.8 ± 4.3 | 13.6 ± 4.0 |
| Imputation in UPDRS (n) | 28 (31.5%) | n/r | 6 (37.5%) | 4 (28.6%) | 18 (30.5%) | 12 (34.3%) | 9 (27.3%) | 7 (33.3%) |
| Regularly used walker before baseline (n) | 14 (15.7%) | 3 (3.4%)b | 0 | 2 (14.3%) | 12 (20.3%) | 0 | 2 (6.1%) | 12 (57.1%) |
| Moved to nursing home before baseline (n) | 5 (5.6%) | 0 | 0 | 0 | 5 (8.5%) | 0 | 0 | 5 (23.81%) |
| Progressed to HY5 before baseline (n) | 1 (1.1%) | 0 | 0 | 0 | 1 (1.7%) | 0 | 0 | 1 (4.8%) |
| Developed dementia before baseline (n) | 7 (7.9%) | 7 (7.9%)b | 0 | 1 (7.1%) | 6 (10.2%) | 0 | 0 | 7 (33.3%) |
| Follow-up data | ||||||||
| Years followed since baseline | 8.1 ± 2.7 | 0 | 9.2 ± 1.9 | 9.5 ± 1.4 | 7.5 ± 2.9 | 9.4 ± 1.8 | 8.0 ± 2.7 | 6.1 ± 2.8 |
| Disease duration from onset (yrs) | 16.0 ± 5.4 | 0 | 15.9 ± 4.7 | 17.5 ± 6.4 | 15.7 ± 5.4 | 15.5 ± 4.3 | 15.4 ± 5.9 | 17.9 ± 6.0 |
| Age at end of study or at death (yrs) | 75.7 ± 8.0 | 0 | 73.6 ± 8.9 | 76.2 ± 7.2 | 76.1 ± 7.9 | 74.2 ± 8.3 | 74.5 ± 8.0 | 80.0 ± 5.8 |
| Died (n) | 37 (41.6%) | 0 | 3 (18.8%) | 4 (28.6%) | 30 (50.8%) | 10 (28.6%) | 11 (33.3%) | 16 (76.2%) |
| Age at death (yrs) | 80.0 ± 5.9 | 0 | 80.7 ± 7.2 | 83.0 ± 2.0 | 79.5 ± 6.2 | 81.3 ± 6.1 | 76.8 ± 5.3 | 81.4 ± 5.7 |
| Regularly used walker (n) | 58 (67.4%) | 3 (3.4%)a | 8 (50.0%) | 9 (64.3%) | 41 (73.2%) | 20 (57.1%) | 20 (62.5%) | 18 (94.7%) |
| Progressed to HY5 (n) | 32 (36.0%) | 0 | 3 (18.8%) | 4 (28.6%) | 25 (42.4%) | 7 (20.0%) | 10 (30.3%) | 15 (71.4%) |
| Moved to nursing home (n) | 38 (42.7%) | 0 | 4 (25.0%) | 5 (35.7%) | 29 (49.2%) | 10 (28.6%) | 11 (33.3%) | 17 (81%) |
| Dementia (n) | 27 (32.9%) | 7 (7.9%)a | 2 (13.3%) | 3 (25.0%) | 22 (40.0%) | 6 (19.4%) | 8 (25.8%) | 13 (65%) |
| Participation in clinical reexamination (n) | 34 (38.2%) | 0 | 9 (56.3%) | 4 (28.6%) | 21 (35.6%) | 17 (48.6%) | 15 (45.5%) | 2 (9.5%) |
Cohort demographics and variables included in the classification systems for the whole cohort and subsets. Results are shown in mean ± SD of scores or years (yrs) or in absolute nr (percent of available data for the subset) indicated by (n).
aNumber of patients with missing data (% of the whole cohort).
bIndividuals for whom the use of walker or dementia could not be unambiguously extracted from available data.
HY5 Hoehn & Yahr stage 5, RBD symptoms suggestive of Rem-sleep behavioral disorder, NMSQ nonmotor symptom questionnaire, TD Tremor-dominant motor-phenotype, U Undetermined motor-phenotype, PIGD postural stability and gait disorder motor-phenotype, MMP mild-motor-predominant subtype, IM Intermediate subtype, DM diffuse-malignant subtype.