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Carrageenan injection followed by PGE2 injection produces chronic mechanical and thermal pain. The protocol of modeling (A). The mechanical withdrawal threshold (MWT) (B) and thermal withdrawal latency (TWL) (C) of animals that received carrageenan and PGE2 injections. n = 6. **Compared with the normal group, P < 0.01; △△ compared with the NS+PGE2 group, P < 0.01.
