Skip to main content
. 2021 Jul 20;15:665757. doi: 10.3389/fnins.2021.665757

FIGURE 4.

FIGURE 4

Intrahippocampal microinjection of mAb-proB improved the sepsis-associated encephalopathy-induced cognitive impairment. (A) The behavioral intervention flowchart of the experiment. (B) The efficiency of neutralizing mAb-proB in hippocampus tissue. Scale bar = 100 μm. (C,D) The total traveled distance and percentage of time mice spent in the center of the field via open field test (n = 9/group). (E,F) The recognition index of short/long-term memory tasks of the novel object recognition test (n = 9/group). (G,H) The percentage of the time that mice stay in the novel arm of the short/long-term memory tasks in the Y maze test (n = 9/group). Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 vs. sham group; #p < 0.05, ##p < 0.01, LPS + IgG vs. LPS + mAb-proB.