Fig. 6.

PDIA6 promotes PC cells to evade immune surveillance. (A) PD-L1 protein levels were detected through western blot experiments after the downregulation or overexpression of PDIA6. (B) The cytolytic activity of NK-92 cells against PC cells with PDIA6 knockdown or overexpression was assessed using the CCK-8 assay. (C) Effects of PDIA6 knockdown or overexpression on the concentration of Granzyme B, MIP-1α, IFN-γ, and TNF-α in co-culture supernatants of NK cells and PC cells. N = 3. *P < 0.05, **P < 0.01, and ***P < 0.001. Data were mean ± SD. Unpaired Student's t test and one-way ANOVA and two-way ANOVA with Tukey's post-tests.