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Osteogenesis analysis by gene expression. CO-2D-D: 2D co-culture, CO-3D-D: 3D co-culture, O-2D-D: 2D only BMMSC culture, O-3D-D: 3D only BMMSC culture. Statistical significance was attained at *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001
