TABLE 4.

Published clinical trials of remimazolam in general anesthesia. NA = not available/applicable. N = number of patients.

Trial ID	Procedure	Phase	ASA class	N	Primary endpoint	Salt	Dose	Co-treatment	Comparator	Ref
JapicCTI111495	Various surgeries	II	I-II	85	Successful anesthesia	Besylate	Induction:Various maintenance 1 mg/kg/hr	Remifentanil, rocuronium	NA	Doi (2014); Doi et al. (2015)
NCT01937767	Cardiac surgery	II	NA	90	Successful anesthesia	Besylate	Induction 6–12 mg/kg/hr; maintenance ∼1 mg/kg/hr	Fentanyl/remifentanil, rocuronium	Propofol, sevoflurane	Probst et al. (2014, 2015); Bevilacqua et al. (2015)
JapicCTI121973	Various surgeries	II/III	I - II	375	Successful anesthesia	Besylate	Induction 6–12 mg/kg/hr; maintenance ∼1 mg/kg/hr (titration)	Remifentanil, rocuronium	Propofol	Doi et al., (2020a)
NCT03661489	Various surgeries	III	III	67	Successful anesthesia	Besylate	Induction 6–12 mg/kg/hr; maintenance 2 mg/kg/hr	Remifentanil, muscle relaxant	NA	Doi et al., (2020b)