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. 2021 Jul 20;12:700744. doi: 10.3389/fgene.2021.700744

FIGURE 2.

FIGURE 2

Cooperation between minor and major spliceosomes. Feedback regulation in the minor RNPC3(65K) gene is mediated by protein-protein interactions between the U11/U12 di-snRNP bound to the USSE and upstream U2AF1/2 to enhance recognition of an upstream 3′ss. Cp factors denote cleavage and polyadenylation factors. This leads to formation of either productive mRNA translated in the cytoplasm, or unproductive mRNA that is retained in the nucleus. Modified from Verbeeren et al. (2017). Created by BioRender.com.