Table 1.

Brief summary of the clinical features in three VHL patients

	Patient 1	Patient 2	Patient 3
Age	40	40	35
Gender	Male	Female	Female
Systemic VHL involvement	Bilateral renal cell carcinoma and brainstem hemangioblastomas	Kidney cyst and Spinal cord hemangioblastoma (T4 and T5)	Brainstem hemangioblastoma Spinal cord hemangioblastoma (C6)
Duration of ocular VHL	25 years	9 years	21 years
Ocular VHL	One large juxtapapillary RH and several small peripheral RHs	One large juxtapapillary RH and several small peripheral RHs	Multiple small peripheral RHs
Therapies	Intravitreal anti-VEGF (ranibizumab and bevacizumab), laser photocoagulation and radiation	Intravitreal anti-VEGF (ranibizumab), laser photocoagulation and radiation	Laser photocoagulation and radiation, no anti-VEGF was administered
Enucleation	Left eye in 2003 Right eye in 2012a	Right eye in 2009 a	Left eye in 1991 Right eye in 2004 a

^aThe enucleated eye presented in this study.