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. 2021 Jul 20;12:707728. doi: 10.3389/fimmu.2021.707728

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Copyright © 2021 Pyclik, Srutkova, Razim, Hermanova, Svabova, Pacyga, Schwarzer and Górska

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intranasal administration of untreated and heat-treated Bl 7952 differently attenuates the OVA-induced cellular and humoral immune responses. Effect of PBS (PBS/OVA, black box), untreated Bl 7952 (UN Bl 7952/OVA, blue box) and heat-treated Bl 7952 (HT Bl 7952/OVA, orange box) strain on cytokine production was determined in supernatants of OVA-stimulated splenocytes isolated from bacteria or PBS pre-treated and OVA-sensitized and challenged mice. (A) IL-4, (B) IL-5, (C) IL-10 and (D) IFN-γ cytokines are expressed as pg/ml. Levels of OVA-specific (E) IgE as % of β-hexosaminidase release by RBL assay, (F) IgG1, (G) IgG2a, (H) IgA and (I) total IgA antibodies were measured in sera of experimental mice. Values are expressed as boxplot with mean and min to max value bars; each dot represents a single mouse. Significant difference between PBS/OVA and bifidobacteria-treated/OVA experimental groups was calculated by one-way ANOVA with Dunnett’s multiple comparison test *p <.0.05. **p < 0.01.