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. 2021 Jul 20;12:707784. doi: 10.3389/fimmu.2021.707784

Figure 3.

Figure 3

M1NVs could inhibit the migration and invasion of EM-ESCs directly or through reprogramming of M2 macrophages. (A, F) Co-culture pattern diagram of the migration and invasion assays. (B–E) Migration (B, C) and invasion (D, E) of EM-ESCs treated with NVs derived different type of macrophages, and M1NVs could inhibit the migration and invasion of EM-ESCs (Scale bar =100 μm). (G–J) Migration (G, H) and invasion (I, J) of EM-ESCs treated by different type of macrophages (Scale bar =100 μm). (ns: no significance when compared with blank. NS: no significance when compared with M0. *P<0.05; **P<0.01, ****P<0.0001 when compared with blank. #P<0.05; ####P<0.0001 when compared with M0 macrophages.