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. 2021 Jul 20;12:707784. doi: 10.3389/fimmu.2021.707784

Figure 4.

Figure 4

M1NVs could inhibit HUVEC tube formation in vitro in direct and indirect way. (A, D, G) Co-culture pattern diagram of HUVEC tube formation. (B, C) Tube formation of HUVECs treated with NVs directly (Scale bar =100 μm). (ns: no significance when compared with blank. **P<0.01, ***P<0.001 when compared with blank. #P<0.05, ###P<0.001 when compared with M0NVs). (E, F) Tube formation of HUVECs treated with different types of macrophages (Scale bar =100 μm). (ns: no significance when compared with blank. ***P<0.001 when compared with blank. ####P<0.0001 when compared with M2). (H, I) Tube formation of HUVECs treated with ESCs which were cocultured with different types of macrophages (Scale bar = 100 μm). (*P<0.05, ***P<0.001 when compared with blank. ns, No significance when compared with Co-ESCs. NS, No significance when compared with EM-ESCs. #P<0.05 when compared with EM-ESCs).