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. 2021 Jul 20;11:594917. doi: 10.3389/fonc.2021.594917

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Copyright © 2021 Ferreira, Narvaez, Espíndola, Rosario, Lima and Monteiro

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evolution of pancreatic cancer. Pancreatic cancer appears through proliferative lesions PanINs (located in the pancreatic ducts), evolving to PanIN-1 (low grade lesions with infiltration of the carcinoma and accumulation of genetic alterations and infiltration), intermediate lesions with progression histological, hyperplasia, and primary carcinoma) and PanIN3 (high grade lesions with metastasis, called “carcinoma in situ”) and finally pancreatic ductal adenocarcinoma (the most prevalent and lethal form of this type of neoplasia). From: Author. This figure used elements from Servier Medical Art.