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. 2021 Jul 20;11:594917. doi: 10.3389/fonc.2021.594917

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Copyright © 2021 Ferreira, Narvaez, Espíndola, Rosario, Lima and Monteiro

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular structure of nimesulide. Nimesulide (N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide) is a non-steroidal anti-inflammatory (NSAID), which contains a methylsulfonamide portion in its structure and is a weak acid. It has an acidity constant ranging from 6.4 to 6.8, and the melting point occurs between 147°C and 148°C. In addition, it has good solubility in acetone, chloroform, and ethyl acetate, with relative solubility in ethanol, and low solubility in water. This figure is from: https://pubchem.ncbi.nlm.nih.gov/compound/Nimesulide (accessed on Mar. 14, 2020).