Figure 6.

Pol ι promotes ESCC cell proliferation through G6PD activation in vivo. (A) the tumor volume of xenograft nude mice with different Pol ι expression. Mice were divided into three groups when the average tumor size grew up to 300 mm³. 5 mg/kg polydatin was intraperitoneally injected every other day. Same volume of normal saline was used as control. (B) relative G6PD activity in tumor tissue. (C) hematoxylin and eosin (HE) staining and immunohistochemical staining of Pol ι, OGT and protein O-GlcNAcylation in tumors. **P < 0.01, ***P < 0.001. Scale bar = 100 μm.