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. 2021 Jul 20;12:706528. doi: 10.3389/fphys.2021.706528

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Copyright © 2021 Chi, Liu, Cofano, Patel, Jacinto and Weiss.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dot plots for the transfer coefficient (K_i) of ¹⁴C-AIB in the examined brain regions of the control group [middle cerebral artery occlusion (MCAO)/reperfusion] and the Rapalink-1 group (MCAO/reperfusion + Rapalink-1) after 1 h of MCAO and 2 h of reperfusion. Each bar represents the mean value of each brain region. A two-way ANOVA followed by the Tukey's test for multiple comparisons was used. The K_i for ¹⁴C-AIB was increased with Rapalink-1 in the IR-C and in the CC. n = 10 in each group. IR-C, ischemic-reperfused cortex; CC, contralateral cortex; IH, ipsilateral hippocampus; CH, contralateral hippocampus; CBLL, cerebellum. *p < 0.05 vs. the control group (MCAO/reperfusion). ^†p < 0.05 vs. pons. ^‡p < 0.05 vs. IR-C.