Table 2. Primary and Secondary Clinical Outcomesa.
Outcome | Patients, % | Effect variable | Odds ratio (95% CI) | ||
---|---|---|---|---|---|
DTAS (n = 74) | DTCT (n = 73) | Unadjusted | Adjusted | ||
Shift analysis | |||||
90-d mRS scoreb | NA | NA | Common odds ratio | 2.0 (1.1-3.7) | 2.2 (1.2-4.1) |
90-d mRS score (unified 5-6) | NA | NA | Common odds ratio | 2.1 (1.2-3.7) | 2.2 (1.2-4.0) |
90-d mRS score | |||||
0-2 | 43.2 | 27.4 | Odds ratio | 2.0 (1.0-4.0) | 2.0 (0.8-4.8) |
0-3 | 58.1 | 45.2 | Odds ratio | 1.7 (0.9-3.2) | 1.9 (0.8-4.3) |
90-d mortalitya | 21.3 | 32.9 | Odds ratio | 0.6 (0.3-1.1) | 0.5 (0.2-1.2) |
Abbreviations: DTAS, direct transfer to angiography suite; DTCT, direct transfer to computed tomography; mRS, modified Rankin Scale; NA, not applicable.
Primary and secondary efficacy outcomes were evaluated in the modified intention-to-treat population, defined as patients with large vessel occlusion, whereas 90-day mortality was evaluated in all patients. The DTAS protocol improved clinical outcome, showing an adjusted common odds ratio of improvement of 1 point on the mRS score of 2.2.
The mRS scores of functional disability range from 0 (no symptoms) to 6 (death), with a score of 2 or lower indicating functional independence.