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Knockdown of USP10 decreases the half-life of NHE3. A, Caco-2bbe/NHE3 expressing shCon or shUSP10 were treated with cycloheximide for indicated time duration. NHE3 expression was determined by Western blotting. Representative blots from three independent experiments are shown. B, The graph represents NHE3 expression levels normalized to β-actin. *, P < .05, **, P < .01 versus shCon
