Table 2. Chemical modifications and sequences of Aim2 hydrophobically modified siRNAs.

Name		Sequence
Aim2	Sense	(mU)#(mU)#(fU)(mG)(fU)(mA)(fA)(mA)(fA)(mG)(mU)(mU)(fU)#(mU)#(mA)-TegChol
siRNA 1	Antisense	P(mU)#(fA)#(mA)(fA)(fA)(fC)(mU)(fU)(mU)(fU)(mA)(fC)(mA)#(fA)#(mA)#(fG)#(mA)#(mA)#(mG)#(fA)
Aim2	Sense	(mG)#(mC)#(fU)(mG)(fA)(mA)(fA)(mG)(fC)(mU)(mA)(mU)(fA)#(mA)#(mA)-TegChol
siRNA 2	Antisense	P(mU)#(fU)#(mU)(fA)(fU)(fA)(mG)(fC)(mU)(fU)(mU)(fC)(mA)#(fG)#(mC)#(fA)#(mC)#(mC)#(mG)#(fU)
AIM2	Sense	(mG)#(mU)#(fU)(mG)(fA)(mA)(fU)(mU)(fA)(mU)(mA)(mU)(fG)#(mC)#(mA)-TegChol
siRNA 1	Antisense	P(mU)#(fG)#(mC)(fA)(fU)(fA)(mU)(fA)(mA)(fU)(mU)(fC)(mA)#(fA)#(mC)#(fU)#(mU)#(mC)#(mU)#(fG)
AIM2	Sense	(mU)#(mU)#(fU)(mG)(fU)(mA)(fA)(mA)(fA)(mG)(mU)(mU)(fU)#(mU)#(mA)-TegChol
siRNA 2	Antisense	P(mU)#(fA)#(mA)(fA)(fA)(fC)(mU)(fU)(mU)(fU)(mA)(fC)(mA)#(fA)#(mA)#(fG)#(mA)#(mA)#(mG)#(fA)
Control	Sense	(fU)#(mG)#(fA)(mC)(fA)(mA)(fA)(mU)(fA)(mC)(fG)(mA)(fU)#(mU)#(fA)-TegChol
siRNA	Antisense	V(mU)#(fA)#(mA)(fU)(mC)(fG)(mU)(fA)(mU)(fU)(mU)(fG)(mU)#(fC)#(mA)#(fA)#(mU)#(fC)#(mA)#(fU)

Note: Aim2 siRNA 1 and AIM2 siRNA 2 are single siRNAs that target mRNA sequence shared between mouse and human AIM2. Chemical modifications are designated as follows: m = 2'-O-methyl, f = 2'-fluoro, P = 5′-phosphate, and V = 5′-vinylphosphonate. #, phosphorothioate bond; (), phosphodiester bond; TegChol, 3′-tetraethylene glycol (Teg) cholesterol conjugate.