Table 3.
Comparison of carcinogenicity caused by reaction‐based and enzyme‐based dysregulations in LUAD and LUSC, respectively. Flux fold change (LFC) is denoted as log2 fold change between cancer and healthy states; LFC was computed as log2(r cancer/r normal). η S and η E indicate the average similarity ratio and fuzzy equal membership grade, respectively. H, proton; PEP, phosphoenolpyruvate; DTDP, deoxythymidine‐5'‐diphosphate; ADP, adenosine diphosphate; DADP, deoxyadenosine diphosphate; PYR, pyruvate; ATP, adenosine triphosphate; DTTP, deoxythymidine‐5'‐triphosphate; DATP, deoxyadenosine triphosphate.
| Dysregulated reactions/genes | Reactions | LUAD | LUSC | ||
|---|---|---|---|---|---|
| LFC | (η S , η E ) | LFC | (η S , η E ) | ||
| R_PYK | H + ADP + PEP → ATP + PYR | 3.753 | (0.829, 0.723) | 3.128 | (0.876, 0.754) |
| R_RE2954C | H + PEP + DTDP ↔ PYR + DTTP | 3.671 | (0.843, 0.745) | 3.687 | (0.867, 0.738) |
| R_r0280 | H + PEP + DADP → PYR + DATP | 3.901 | (0.830, 0.714) | 3.361 | (0.882, 0.760) |
| R_RE2954C + R_r0280 |
H + PEP + D PYR + DTTP H + PEP + DADP → PYR + DATP |
2.620 2.324 |
(0.841, 0.743) |
2.60 2.239 |
(0.868, 0.740) |
| PKM |
H + ADP + PEP → ATP + PYR H + PEP + DTDP ↔ PYR + DTTP |
2.260 2.868 |
(0.842, 0.761) |
1.857 2.424 |
(0.860, 0.728) |
| PKLR |
H + ADP + PEP → ATP + PYR H + PEP + DADP → PYR + DATP |
2.563 2.878 |
(0.830, 0.715) |
2.395 2.680 |
(0.869, 0.752) |
| PKM + PKLR |
H + ADP + PEP → ATP + PYR H + PEP + DTDP ↔ PYR + DTTP H + PEP + DADP → PYR + DATP |
1.749 2.300 2.019 |
(0.848, 0.754) |
1.735 2.286 1.984 |
(0.863, 0.717) |