TABLE 3.
Meta-analysis of the association between MCT1 gene Glu490Asp polymorphism and endurance athletic status.
| Group | Total number | T/T + T/A genotypes | A/A genotype | |
|---|---|---|---|---|
| Athletes | Controls | OR (95% CI) | OR (95% CI) | |
| Caucasian Brazilians† | 77 | 586 | 1.13 (0.58–2.22) | 0.88 (0.45–1.74) |
| European Cohort | 315 | 552 | 1.63 (1.08–2.46) | 0.61 (0.41–0.92) |
| Total | 392 | 1138 | 1.48 (1.04–2.10) | 0.68 (0.48–0.96) |
| Test for overall effect | – | – | Z = 2.18 (P = 0.03) | Z = 2.18 (P = 0.03) |
| Heterogeneity | – | – | χ² = 0.82 (P = 0.36) | χ² = 0.82 (P = 0.36) |
| Brazilian Cohort‡ | 195 | 890 | 1.51 (0.92–2.49) | 0.66 (0.40–1.09) |
| European Cohort | 315 | 552 | 1.63 (1.08–2.46) | 0.61 (0.41–0.92) |
| Total | 510 | 1442 | 1.58 (1.15–2.17) | 0.63 (0.46–0.87) |
| Test for overall effect | – | – | Z = 2.83 (P = 0.005) | Z = 2.83 (P = 0.005) |
| Heterogeneity | – | – | χ² = 0.06 (P = 0.81) | χ² = 0.06 (P = 0.81) |
†
Only data from Caucasian international-level athletes were considered for the meta-analysis, given that a difference was identified between Caucasian athletes of international-level and their counterparts of lower competitive level.
‡
Data from Afro-descendant Brazilians were added to the previous analysis, containing only Caucasian Brazilians. All Afro-descendant athletes were considered for the meta-analysis.