Table II.
Genotype and allele frequencies of IL-6 and TNF-α gene polymorphisms in the 200 patients with IS and the 200 control individuals, and their associations with the risk of IS susceptibility.
| A, IL-6-174G/C | |||||
|---|---|---|---|---|---|
| Polymorphism | IS patients, n (%) | Controls, n (%) | P-valueb | OR (95% CI) | P-valuec |
| Genotype | |||||
| GG | 190 (95.0) | 188 (94.0) | 0.959 | 1.000 | |
| GC | 10 (5.0) | 12 (6.0) | 0.832 | 0.825 (0.348-1.955) | 0.661 |
| CC | 0 (0.0) | 0 (0.0) | |||
| Allele | |||||
| G | 390 (97.5) | 388 (97.0) | 0.971 | 1.000 | |
| C | 10 (2.5) | 12 (3.0) | 0.832 | 0.829 (0.354-1.941) | 0.666 |
| MAF (%) | 2.5 | 3.0 | |||
| B, TNF-α-308G/A | |||||
| Genotype | |||||
| GG | 166 (83.0) | 181 (92.1) | 0.452 | 1.000 | |
| GA | 31 (15.5) | 19 (7.9) | 0.119 | 1.747 (0.951-3.211) | 0.072 |
| AA | 3 (1.5) | 0 (0.0) | 0.250 | ||
| GA+AA | 34 (17.0) | 19 (7.9) | 0.053 | 1.951 (1.071-3.554) | 0.029a |
| Allele | |||||
| G | 363 (90.7) | 381 (95.2) | 0.533 | 1.000 | |
| A | 37 (9.3) | 19 (4.8) | 0.022a | 2.044 (1.154-3.620) | 0.014a |
| MAF (%) | 9.3 | 4.8 | |||
aP<0.05.
bCalculated using a binomial test.
cCalculated using multivariate logistic regression. OR (95% CI) were calculated using a multivariate logistic regression model. IS, ischemic stroke; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval.