Table III.
Associations of IL-6 and TNF-α gene polymorphisms with the risk of IS development according to different modes of inheritance.
| A, IL-6-174G/C | ||
|---|---|---|
| Polymorphism | Adjusted OR (95% CI) | P-value |
| C dominance, G wild type | ||
| GG | 1.000 | |
| GC or CC | 0.801 (0.337-1.907) | 0.617 |
| C recessive, G wild type | ||
| GG or GC | 1.000 | |
| CC | 1.162 (0.072-18.805) | 0.916 |
| B, TNF-α-308G/A | ||
| Polymorphism | Adjusted OR (95% CI) | P-value |
| A dominance, G wild type | ||
| GG | 1.000 | |
| GA or AA | 1.971 (1.080-3.599) | 0.027a |
| A recessive, G wild type | ||
| GG or GA | 1.000 | |
| AA | 4.138 (0.456-37.544) | 0.207 |
aP<0.05. P-values were calculated using multivariate logistic regression analysis. The adjusted OR (95% CI) was calculated using multivariate logistic regression after adjustment for sex. Variables in the model include IL-6-174G/C and TNF-α-308G/A. Method of variables entry in the model: Enter method. OR, odds ratio; CI, confidence interval.