Table IV.
Interaction of IL-6-174G/C polymorphism with clinical factors, as determined using multivariate logistic regression analysis.
| Polymorphism | Clinical factor | IS patients, n=200 | Controls, n=200 | Adjusted OR (95% CI) | P-value |
|---|---|---|---|---|---|
| IL-6-174G/C | Hypertension | ||||
| GG | No | 45 | 113 | 1.000 | |
| GC | No | 1 | 9 | 0.087 (0.009-0.797)c | 0.031a |
| GG | Yes | 145 | 75 | 4.095 (2.604-6.441)c | <0.001b |
| GC | Yes | 9 | 3 | 2.372 (0.571-9.852)c | 0.235 |
| IL-6-174G/C | Hyperlipidemia | ||||
| GG | No | 89 | 141 | 1.000 | |
| GC | No | 5 | 8 | 0.791 (0.219-2.852)d | 0.720 |
| GG | Yes | 101 | 47 | 2.979 (1.850-4.797)d | <0.001b |
| GC | Yes | 5 | 4 | 0.705 (0.164-3.030)d | 0.639 |
| IL-6-174G/C | Smoking | ||||
| GG | No | 138 | 152 | 1.000 | |
| GC | No | 5 | 9 | 0.449 (0.126-1.597)e | 0.216 |
| GG | Yes | 52 | 36 | 1.608 (0.929-2.784)e | 0.090 |
| GC | Yes | 5 | 3 | 1.763 (0.315-9.866)e | 0.519 |
| IL-6-174G/C | Alcohol drinking | ||||
| GG | No | 151 | 164 | 1.000 | |
| GC | No | 5 | 10 | 0.488 (0.140-1.705)f | 0.261 |
| GG | Yes | 39 | 24 | 1.968 (1.050-3.688)f | 0.035a |
| GC | Yes | 5 | 2 | 1.967 (0.317-12.193)f | 0.468 |
aP<0.05,
bP<0.001. P-values were calculated using multivariate logistic regression analysis. The adjusted OR (95% CI) was calculated via multivariate logistic regression analysis after adjustment for
csex, age, diabetes mellitus, metabolic syndrome, hyperlipidemia, smoking and drinking;
dsex, age, diabetes mellitus, metabolic syndrome, hypertension, smoking and drinking;
esex, age, diabetes mellitus, metabolic syndrome, hypertension, hyperlipidemia and drinking;
fsex, age, diabetes mellitus, metabolic syndrome, hypertension, hyperlipidemia and smoking. IS, ischemic stroke; OR, odds ratio; CI, confidence interval.