Table V.
Interaction of the TNF-α-308G/A polymorphism with clinical factors, as determined using multivariate logistic regression analysis.
| Polymorphism | Clinical factor | IS patients, n=200 | Controls, n=200 | Adjusted OR (95% CI) | P-value |
|---|---|---|---|---|---|
| TNF-α-308G/A | Hypertension | ||||
| GG | No | 42 | 110 | 1.000 | |
| GA+AA | No | 4 | 12 | 0.448 (0.133-1.513)c | 0.196 |
| GG | Yes | 124 | 71 | 2.655 (1.721-4.094)c | <0.001b |
| GA+AA | Yes | 30 | 7 | 4.585 (1.892-11.110)c | 0.001b |
| TNF-α-308G/A | Hyperlipidemia | ||||
| GG | No | 79 | 135 | 1.000 | |
| GA+AA | No | 15 | 14 | 1.291 (0.546-3.054)d | 0.560 |
| GG | Yes | 87 | 46 | 2.253 (1.401-3.624)d | 0.001b |
| GA+AA | Yes | 19 | 5 | 3.016 (1.027-8.862)d | 0.045a |
| TNF-α-308G/A | Smoking | ||||
| GG | No | 118 | 145 | 1.000 | |
| GA+AA | No | 25 | 16 | 1.466 (0.686-3.134)e | 0.324 |
| GG | Yes | 48 | 36 | 1.404 (0.800-2.462)e | 0.237 |
| GA+AA | Yes | 9 | 3 | 4.010 (0.889-18.092)e | 0.071 |
| TNF-α-308G/A | Alcohol drinking | ||||
| GG | No | 126 | 156 | 1.000 | |
| GA+AA | No | 30 | 18 | 1.650 (0.811-3.355)f | 0.167 |
| GG | Yes | 40 | 25 | 1.934 (1.037-3.608)f | 0.038a |
| GA+AA | Yes | 4 | 1 | 2.721 (0.288-25.693)f | 0.382 |
aP<0.05,
bP≤0.001. P-values were calculated using multivariate logistic regression analysis. The adjusted OR (95% CI) was calculated via multivariate logistic regression analysis after adjustment for
csex, age, diabetes mellitus, metabolic syndrome, hyperlipidemia, smoking and drinking;
dsex, age, diabetes mellitus, metabolic syndrome, hypertension, smoking and drinking;
esex, age, diabetes mellitus, metabolic syndrome, hypertension, hyperlipidemia and drinking;
fsex, age, diabetes mellitus, metabolic syndrome, hypertension, hyperlipidemia and smoking. IS, ischemic stroke; OR, odds ratio; CI, confidence interval.