Table 1.
Differences (red) and similarities (green) between enteroviruses and coronaviruses
| Attribute | Enteroviruses | Coronaviruses |
|---|---|---|
| Virion size | small, 30 nm | large, 120–160 nm |
| Genome size | 7–7,5 kb | 30 kb |
| Structure | Non-enveloped | Enveloped |
| Infection route | Fecal-oral and respiratory route | Respiratory route |
| Uncoating/release from vesicles | Largely independent of low pH | Dependent on low pH |
| Genome release | In endosomes, through endosomal membrane | In the cytoplasm, with assistance from proteasomes |
| Genome | ssRNA+ polarity | ssRNA + polarity |
| Polyprotein processing | By viral proteases | By viral proteases |
| Major protease | 3 C protease (3 Cpro) | Main protease (Mpro) |
| Protein-primed RNA synthesis | yridylylation of Nsp9 and Nsp8 | yridylylation of VPg |
| Severe epidemic causing serotypes | EV-D68, EV-A71, EV30 | SARS Cov-1, SARS CoV-2, MERS |