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. 2021 Aug 3;7:11. doi: 10.1186/s40733-021-00077-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — A schematic representation of the main characteristics of the 4 clusters identified in this study. Clusters 1 and 3 seem to have a more positive pattern of treatment outcomes and were characterized by more prominent atopic markers and a predominant allelic (A) effect for rs37973, a polymorphism in the GLCCI1 gene, and with a relatively later onset of disease. Clusters 2 and 4 had poorer treatment success patterns and were characterized by higher levels of airway and systemic inflammation and comorbidities, but varied in the type of inflammation (predominantly neutrophilic for cluster 4 and mixed-type for cluster 2) and platelet count (lowest for cluster 4). Cluster 2 was the only one with relatively earlier onset of asthma (5 years of age)