Table 3.

Response variables assessed at each visit (compared to a previous one- 6, 12 and 18 months after baseline). Response to treatment is defined into more detail in the supplementary file (Table S3). ppb- parts per billion

	FEV1	MEF50	FENO	Asthma control
Good	Increase ≥ 10% predicted	Increase ≥ 15% predicted	Decrease < 20% for FENO values > 35 (50) ppb or increase < 10 ppb for FENO values < 35 (50) ppb	improvement in asthma control
Moderate	± 9% predicted	± 14% predicted	≤ 20% FENO ≤ 20% for FENO values over 35 (50) ppb or  ± 10 ppb for FENO values < 35 (50) ppb	no changes in partial asthma control
Poor	Decrease ≤  (-10%) predicted	Decrease  ≤ (-15%) predicted	Increase > 20% for FENO values > 35 (50) ppb or increase > 10 ppb for FENO values < 35 (50) ppb	deterioration in asthma control