Table 5.
Response to treatment (outcome)- related cluster statistics. Ward`s Euclidean method, χ2 test, p < 0.05. Abbreviations for respective responses to treatment are defined in Supplement Table 1
| Feature / No of patients | Cluster 1 (N = 58) | Cluster 2 (N = 87) | Cluster 3 (N = 138) | Cluster 4 (N = 64) | p-value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Good N (%) |
Moderate N (%) |
Poor N (%) |
Good N (%) |
Moderate N (%) |
Poor N (%) |
Good N (%) |
Moderate N (%) |
Poor N (%) |
Good N (%) |
Moderate N (%) |
Poor N (%) |
||
|
Resp FEV1 baseline to 1st control |
17 (29.31) |
27 (46.55) |
14 (24.14) |
8 (9.2) |
45 (51.72) |
34 (39.08) |
75 (54.35) |
49 (35.51) |
14 (10.14) |
19 (29.69) |
24 (37.5) |
21 (32.81) |
< 0.001 |
| Resp FENO baseline to 1st control |
1 (1.72) |
57 (98.28) |
0 (0) |
79 (90.8) |
7 (8.05) |
1 (1.15) |
108 (78.26) |
14 (10.14) |
16 (11.59) |
58 (90.62) |
4 (6.25) |
3 (3.12) |
< 0.001 |
| Resp CTRL baseline to 1st control |
34 (58.62) |
12 (20.69) |
12 (20.69) |
55 (63.22) |
22 (25.29) |
10 (11.49) |
94 (68.12) |
16 (11.59) |
28 (20.29) |
34 (53.12) |
11 (17.19) |
19 (29.69) |
< 0.05 |
| Resp MEF50 baseline to 1st control |
18 (31.03) |
22 (37.93) |
18 (31.03) |
5 (5.75) |
43 (49.43) |
39 (44.83) |
75 (54.35) |
43 (31.16) |
20 (14.49) |
20 (31.25) |
22 (34.38) |
22 (34.38) |
< 0.001 |
| Resp FEV1 1st to 2nd control |
9 (15.52) |
46 (79.31) |
3 (5.17) |
10 (11.49) |
64 (73.56) |
13 (14.94) |
44 (31.88) |
70 (50.72) |
24 (17.39) |
18 (28.12) |
40 (62.5) |
6 (9.38) |
< 0.001 |
| Resp FENO 1st to 2nd control |
48 (82.76) |
10 (17.24) |
0 (0) |
55 (63.22) |
21 (24.14) |
11 (12.64) |
84 (60.87) |
30 (21.74) |
24 (17.39) |
39 (60.94) |
14 (21.88) |
11 (17.19) |
< 0.05 |
| Resp CTRL 1st to 2nd control |
52 (89.66) |
2 (3.45) |
4 (6.9) |
59 (67.82) |
11 (12.64) |
17 (19.54) |
118 (85.51) |
4 (2.9) |
16 (11.59) |
46 (71.88) |
6 (9.38) |
12 (18.75) |
< 0.01 |
| Resp FEV1 2nd to 3rd control |
3 (5.17) |
45 (77.59) |
10 (17.24) |
11 (12.64) |
73 (83.91) |
3 (3.45) |
21 (15.22) |
89 (64.49) |
28 (20.29) |
4 (6.25) |
42 (65.62) |
18 (28.12) |
< 0.001 |
| Resp FENO 2nd to 3rd control |
16 (27.59) |
26 (44.83) |
16 (27.59) |
29 (33.33) |
48 (55.17) |
10 (11.49) |
54 (39.13) |
75 (54.35) |
9 (6.52) |
23 (35.94) |
29 (45.31) |
12 (18.75) |
< 0.01 |
| Resp CTRL 2nd to 3rd control |
53 (91.38) |
3 (5.17) |
2 (3.45) |
82 (94.25) |
5 (5.75) |
0 (0) |
128 (92.75) |
6 (4.35) |
4 (2.9) |
2 (3.12) |
9 (14.06) |
53 (82.81) |
< 0.001 |
| Resp MEF50 2nd to 3rd control |
3 (5.17) |
41 (70.69) |
14 (24.14) |
20 (22.99) |
57 (65.52) |
10 (11.49) |
38 (27.54) |
76 (55.07) |
24 (17.39) |
4 (6.25) |
36 (56.25) |
24 (37.5) |
< 0.001 |
| Resp FEV1 baseline to 2nd control |
22 (37.93) |
23 (39.66) |
13 (22.41) |
6 (6.9) |
42 (48.28) |
39 (44.83) |
79 (57.25) |
54 (39.13) |
5 (3.62) |
19 (29.69) |
30 (46.88) |
15 (23.44) |
< 0.001 |
| Resp FENO baseline to 2nd control |
7 (12.07) |
0 (0) |
51 (87.93) |
13 (14.94) |
65 (74.71) |
9 (10.34) |
25 (18.12) |
90 (65.22) |
23 (16.67) |
14 (21.88) |
42 (65.62) |
8 (12.5) |
< 0.001 |
| Resp CTRL baseline to 2nd control |
50 (86.21) |
6 (10.34) |
2 (3.45) |
61 (70.11) |
16 (18.39) |
10 (11.49) |
120 (86.96) |
10 (7.25) |
8 (5.8) |
42 (65.62) |
10 (15.62) |
12 (18.75) |
< 0.01 |
| Resp MEF50_diagn to 2nd control |
17 (29.31) |
27 (46.55) |
14 (24.14) |
3 (3.45) |
36 (41.38) |
48 (55.17) |
74 (53.62) |
60 (43.48) |
4 (2.9) |
14 (21.88) |
35 (54.69) |
15 (23.44) |
< 0.001 |
| Resp FEV1 baseline to 3rd control |
19 (32.76) |
20 (34.48) |
19 (32.76) |
8 (9.2) |
49 (56.32) |
30 (34.48) |
71 (51.45) |
62 (44.93) |
5 (3.62) |
8 (12.5) |
39 (60.94) |
17 (26.56) |
< 0.001 |
| Resp FENO baseline to 3rd control |
12 (20.69) |
25 (43.1) |
21 (36.21) |
15 (17.24) |
56 (64.37) |
16 (18.39) |
34 (24.64) |
86 (62.32) |
18 (13.04) |
10 (15.62) |
37 (57.81) |
17 (26.56) |
< 0.01 |
| Resp CTRL baseline to 3rd control |
53 (91.38) |
5 (8.62) |
0 (0) |
81 (93.1) |
6 (6.9) |
0 (0) |
135 (97.83) |
3 (2.17) |
0 (0) |
4 (6.25) |
20 (31.25) |
40 (62.5) |
< 0.001 |
| Resp MEF50 baseline to 3rd control |
11 (18.97) |
30 (51.72) |
17 (29.31) |
5 (5.75) |
37 (42.53) |
45 (51.72) |
71 (51.45) |
61 (44.2) |
6 (4.35) |
4 (6.25) |
36 (56.25) |
24 (37.5) |
< 0.001 |