Table 4.
Univariate analysis of covariates associated with mortality in patients with primary hemophagocytic lymphohistiocytosis
| Variables | Mean survival in days (95% confidence interval) |
P-value |
|---|---|---|
| Splenomegaly | ||
| Yes | 935.9 (678.5-1193.4) | 0.069 |
| No | 37 (1.72-72.3) | |
| BM. hemophagocytosis | ||
| Yes | 146.0 (24.9-267.1) | 0.059 |
| No | 977.2 (710.2-1244.2) | |
| CNS involvement | ||
| Yes | 655.6 (304.0-1007.0) | 0.092 |
| No | 849.3 (657.7-1040.9) | |
| Bleeding tendency | ||
| Yes | 195.8 (24.5-367.1) | 0.059 |
| No | 960.1 (695.9-1224.2) | |
| Bicytopenia | ||
| Yes | 801.7 (540.0-1063.4) | 0.052 |
| No | 845.2 (652.5-1037.8) | |
| Platelet count | ||
| <100,000/μL | 711.2 (443.8-978.7) | 0.001* |
| ≥ 100,000/μL | 1195.2 (1001.1-1389.3) | |
| Hemoglobin | ||
| < 9 g/dL | 844.0 (562.9-1125.2) | 0.188 |
| ≥ 9 g/dL | 808.1 (547.3-1068.9) | |
| Total bilirubin | ||
| > 1 mg/dL | 571.2 (275.5-867.0) | 0.008* |
| ≤ 1 mg/dL | 1004.3 (781.7-1226.8) | |
| ESR | ||
| > 20 mm/hr | 1271.7 (934.8-1608.6) | 0.002* |
| ≤ 20 mm/hr | 459.4 (298.7-620.1) | |
| Fibrinogen | ||
| < 150 mg/dL | 1001.8 (660.1- 1343.5) | 0.183 |
| ≥ 150 mg/dL | 658.7 (405.4-912.1) | |
ULN upper limit of normal, ALT alanine aminotransferase, ESR Erythrocyte sedimentation rate, CNS central nervous system, BM bone marrow
†The data were analyzed by the Log-rank test; only variables with P < 0.2 are shown
*Statistically significant