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. 2021 Aug 3;16:51. doi: 10.1186/s13024-021-00472-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Granulins F levels in FTLD-TDP-Pgrn subjects versus controls. a, Western blot analysis of endogenous PGRN and Gran-F in IOC and MFG regions of control human brain. b, Quantification of PGRN and Gran-F levels in IOC and MFG regions in control subjects (ns, not significant). c, Western blot analysis of endogenous PGRN and Gran-F in IOC and MFG regions of FTLD-TDP-Pgrn subjects. d, Quantification of PGRN and Gran-F levels in IOC and MFG regions in FTLD-TDP-Pgrn subjects (*, p = 0.03). Error bars represent mean with standard deviation. Paired student-t test was performed between each pair. Sample numbers listed below each Western blot correspond to subject number in Table 2