Table 5.
Outcomes of the included studies
| Publications | N | Institution | Country | Macroscopy (atrophy pattern) | Microscopy | |
|---|---|---|---|---|---|---|
| 1 | [52] | 1 | UCL | UK | Frontotemporal predominant R-FT = L-FT | TDP type C + CTD |
| 2 | [69] | 1 | MCCN | UK | Temporal predominant R-T = L–T | Tau-PSP + TDP type A |
| 3 | [54] | 9 | UCSF | USA |
Frontotemporal predominant R-FT = L-FT (n = 1) TDP-C: N.A |
Tau-PiD (n = 1) TDP type C (n = 8) |
| 4 | [61] | 1 | UCSF | USA | N.A | TDP type C + Tau-PSP |
| 5 | [63] | 1 | UCL | UK | Temporal predominant R-T = L–T | TDP type A |
| 6 | [64] | 1 | Helsinki University | Finland | Frontotemporal predominant R-FT = L-FT | TDP type A |
| 7 | [70] | 1 | Cambridge Brain Bank | UK | Temporal predominant R-T = L–T | Tau-MAPT |
| 8 | [55] | 1 | UCL | UK | Frontotemporal predominant R-FT > L-FT | Tau-GGT |
| 9 | [67] | 1 | UCSF | USA | Frontotemporal predominant R-FT > L-FT | TDP type A-B + AD + 4R tau |
| 10 | [38] | 7 | Mayo Clinic | USA | Individual data N.A. Overall, temporal predominant |
TDP type C (n = 1) TDP type C + CTD (n = 6) |
| 11 | [56] | 2 | Mayo Clinic | USA | N.A |
TDP type B + MND* (n = 1) TDP type B + MND* + AD (n = 1) |
| 12 | [66] | 1 | UCSF | USA | Striatal predominant | FUS |
| 13 | [68] | 1 | Uppsala University | Sweden | Temporal predominant R-T > L–T | TDP type B + MND* |
| 14 | [60] | 1 | UCL | UK | N.A | TDP type A-B |
| 15 | [62] | 1 | Tokyo IP | Japan | Temporal predominant R-T > L–T | TDP type B + MND* |
| 16 | [65] | 1 | Tokyo IP | Japan | Temporal predominant R-T > L–T | TDP type A-B + MND* |
| 17 | [4] | 1 | UCL | UK | N.A | AD + DLB (n = 1) |
| 18 | [38] | 8 | Mayo clinic | USA | N.A |
Tau-PiD (n = 1) Tau-MAPT (n = 7) |
| 19 | [59] | 2 | UCL | UK | N.A | TDP type A-B (n = 2) |
| 20 | [71] | 1 | Aichi University | Japan | Frontotemporal predominant R-FT = L-FT | TDP type A-B + AD |
| 21 | [58] | 1 |
Northwestern University |
USA | N.A | TDP type A-B + MND* |
TDP: TAR DNA-binding protein 43; TAU: tau protein; CTD: corticospinal tract degeneration; MND: motor neuron disease; MAPT: microtubule associated protein; FUS: fused in sarcoma protein; PiD: Pick’s disease; PSP: progressive supranuclear palsy; FTLD-U: frontotemporal lobar degeneration with tau-negative, ubiquitin-immunoreactive pathology; AD: Alzheimer’s disease; DLB: dementia with Lewy bodies; UCL: University College London; UCSF: University of California San Francisco; FTD: frontotemporal dementia; MCCN: Manchester Centre for Clinical Neurosciences; IP: institute of psychiatry; VAPSHCS: Veterans Affairs Puget Sound Health Care System
*Clinically diagnosed with FTD + MND