Table 2.
Univariate and multivariate Cox regression model of variables associated with pregnancy outcomes in AEH/EEC patients after fertility-sparing treatment
| Variables | Non-pregnant | Pregnant | HR (95% CI) P value | ||
|---|---|---|---|---|---|
| N = 32 | N = 36 | Crude model | Adjusted model I | Adjusted model II | |
| Age of pregnancy permission (years) | 32.6 ± 3.8 | 31.2 ± 4.5 | 1.0 (0.9, 1.1) 0.717 | 1.0 (1.0, 1.1) 0.502 | 1.0 (0.9, 1.1) 0.554 |
| BMI of pregnancy permission (kg/m2) | 27.2 ± 3.7 | 24.8 ± 3.6 | 0.9 (0.8, 1.0) 0.061 | 0.9 (0.8, 1.0) 0.045 | 0.9 (0.8, 1.0) 0.031 |
| < 24 | 3 (9.4%) | 18 (50.0%) | Refrence | Refrence | Refrence |
| ≥ 24 | 29 (90.6%) | 18 (50.0%) | 0.4 (0.2, 0.8) 0.012 | 0.4 (0.2, 0.8) 0.010 | 0.4 (0.2, 0.8) 0.010 |
| Additional prolonged therapy (months) | 2.1 ± 2.6 | 2.2 ± 1.9 | 1.0 (0.9, 1.2) 0.794 | 1.0 (0.9, 1.2) 0.705 | 1.0 (0.8, 1.2) 0.770 |
| 0 | 17 (53.1%) | 13 (36.1%) | Refrence | Refrence | Refrence |
| 3 | 9 (28.1%) | 19 (52.8%) | 2.1 (1.0, 4.2) 0.044 | 2.9 (1.2, 7.0) 0.018 | 3.0 (1.1, 8.3) 0.037 |
| ≥ 6 | 6 (18.8%) | 4 (11.1%) | 0.9 (0.3, 2.7) 0.829 | 1.2 (0.3, 4.0) 0.817 | 0.7 (0.2, 2.7) 0.603 |
| Time to CR (months) | 6.4 ± 4.0 | 4.2 ± 2.5 | 0.9 (0.7, 1.0) 0.049 | 0.9 (0.7, 1.0) 0.109 | 0.8 (0.7, 1.0) 0.032 |
| < 6 | 12 (37.5%) | 28 (77.8%) | Refrence | Refrence | Refrence |
| ≥ 6 | 20 (62.5%) | 8 (22.2%) | 0.3 (0.1, 0.7) 0.004 | 0.3 (0.1, 0.8) 0.014 | 0.2 (0.1, 0.6) 0.004 |
| Intrauterine adhesion | |||||
| No | 16 (50.0%) | 26 (72.2%) | Refrence | Refrence | Refrence |
| Yes | 16 (50.0%) | 10 (27.8%) | 0.5 (0.2, 1.1) 0.082 | 0.6 (0.3, 1.4) 0.244 | 0.6 (0.3, 1.4) 0.272 |
| Number of HS | 4.1 ± 1.2 | 3.4 ± 1.0 | 0.7 (0.5, 0.9) 0.007 | 0.7 (0.5, 1.0) 0.024 | 0.6 (0.4, 0.8) 0.004 |
| Endometrial thickness after CR (cm) | 0.6 ± 0.2 | 0.7 ± 0.2 | 5.0 (0.9, 28.8) 0.072 | 7.3 (0.9, 57.3) 0.058 | 8.8 (1.1, 73.0) 0.043 |
| Relapse before pregnancy | |||||
| No | 19 (59.4%) | 30 (83.3%) | Refrence | Refrence | Refrence |
| Yes | 13 (40.6%) | 6 (16.7%) | 0.3 (0.1, 0.7) 0.006 | 0.2 (0.1, 0.6) 0.004 | 0.2 (0.1, 0.5) 0.001 |
Crude model adjust for: None
Adjust model I adjust for: Histological type; Treatment protocol
Adjust model II adjust for: Histological type; Treatment protocol; HOMA; PCO on ultrasonography; Parity
BMI, kg/m2 (Chinese Society for the Study of Obesity: normal BMI 18.5–23.9; overweight 24–28; obesity > 28)
BMI body mass index, CR complete remission, CI confidence interval, HR hazard ratio, HS hysteroscopy, PCO polycystic ovary