Table 2.
Reports of CVST post-Johnson & Johnson COVID-19 vaccination. F: Female, M: Male, N/A: not applicable, CVST: cerebral venous sinus thrombosis, ICH: Intracerebral Hemorrhage, PF4: Platelet Factor4.
| No | Authors | Total no. sex/age | Preexisting conditions / Medications | Time from vaccination (days) | Clinical presentations | Imaging findings | Lab findings | Outcome |
|---|---|---|---|---|---|---|---|---|
| 1 | See et al. [9] | 12 F 8 (18–39) 4(>40) |
Obesity in 6 patients combined oral contraceptives (OCP)in 1 patient |
8.8 days (Range: 6–13) | Headache 11 patients Other symptoms: Back pain, Abdominal pain, lethargy, myalgia, nausea, vomiting, fever, dyspnea, chills, photophobia, cognitive impairment, blurred vision, Right side weakness |
12 CVST in: Transverse sinus, sigmoid sinus, straight sinus, superior sagittal sinus, internal jugular vein with 7 patients ICH and and 8 patients with non-CVST including thromboses including: portal vein thrombosis lower extremity deep vein thrombosis |
Platelet count: Mean: 45.7 (Range:9–127) cells×109/l PF4 IgG Assay: Done in 11 cases, all Positive d-Dimer: Positive in all patients |
4 patients were discharged to home. 3 patients died. Other: intensive care unit (ICU) care: 3 non-ICU hospitalization: 2 |
| 2 | Muir KL et al. [27] |
48 y/o F | 14 days | Malaise and abdominal pain and then Headache |
CVST in the right transverse And straight sinuses. And ICH And splanchnic -vein thrombosis |
Platelet count: Mean: 13 cells×109/l PF4 IgG Assay: Positive d-Dimer: Positive |
Critically ill | |
| Total | 13 F | 6 Patients with Obesity One on OCP |
9.2(Range: 6–14) | Headache most frequent presenting complain | 13 CVST (CVST + ICH/SAH: 8) |
Platelet count: Mean: 43 cells×109/l (Range:9–127) PF4 IgG Assay: Positive in 12 cases Unknown in 2 cases d-Dimer: Positive in all cases |
Discharged: 4 Died: 3 Critically ill:4 non-ICU hospitalization:2 |