Table 2.
Cardiac Troponin Level as a Predictor for 60-Day Mortality and Severe COVID-19 Infection. All models were adjusted for baseline characteristics, pre-existing comorbidities, and initial values of c-reactive protein, lactate dehydrogenase, and ferritin during the index hospitalization
| Normal cTn, ≤ 1x ULN (n = 657) |
Mild cTn Elevation, > 1 to < 2x ULN (n = 69) |
P-value | Severe cTn Elevation, ≥ 2x ULN (n = 46) |
P -value | |
|---|---|---|---|---|---|
| 60-Day Mortality | |||||
| Incidence (%) | 91 (13.9) | 20 (29.0) | 24 (52.2) | - | |
| Model 1 Adjusted OR* (95% CI) | Ref | 1.35 (0.68 – 2.60) | 0.38 | 2.45 (1.13 – 5.25) | < 0.05 |
| Model 2 Adjusted OR† (95% CI) | - | Ref | - | 2.05 (0.74 – 5.78) | 0.17 |
| Severe Infection‡ | |||||
| Incidence (%) | 288 (43.7) | 49 (71.0) | 43 (93.5) | - | |
| Model 3 Adjusted OR*(95% CI) | Ref | 3.00 (1.51 – 6.29) | < 0.01 | 9.96 (2.75 – 64.23) | < 0.01 |
| Model 4 Adjusted OR† (95% CI) | - | Ref | - | 5.97 (0.97 – 72.35) | 0.09 |
cTn = cardiac troponin; ULN = upper limit of normal; OR = odds ratio; CI = confidence interval; Ref = reference
⁎
Model 1 and Model 3 compared both mild and severe cTn elevation to those with normal cTn levels.
†
Model 2 and Model 4 compared severe cTn elevation those with mild cTn elevation.
‡
Severe infection was defined through a composite consisting of 60-day mortality, ICU requirement, and need for non-invasive positive pressure ventilation or intubation