Table 3:
Multivariable Logistic regression Models for Adherence by AET Symptom Domains
| Odds ratio estimates (95% CI) | ||||||
|---|---|---|---|---|---|---|
| Primary model | Subset models | |||||
| Parameters | Total Endocrine Symptoms | Vasomotor Symptoms | Neuropsychological Symptoms | Gynecologic Symptoms | Gastrointestinal Symptoms | Bone Symptoms |
| Symptom score | 0.98 (0.96, 0.995)* | 1.02 (0.96, 1.08) | 0.93 (0.87,0.994)* | 0.92 (0.87, 0.96)*** | 0.96 (0.91, 1.02) | 0.97 (0.85, 1.11) |
| Race (Black vs White) | 0.43 (0.27, 0.67)*** | 0.43 (0.28, 0.68)*** | 0.42 (0.27, 0.66)*** | 0.42 (0.27,0.65)*** | 0.42 (0.27,0.78)*** | 0.46 (0.27, 0.78)** |
| Working status (No vs. Yes) | 1.57 (1.03,2.40)* | 1.65 (1.08, 2.52)* | 1.60 (1.05, 2.44)* | 1.62 (1.06, 2.47)* | 1.62 (1.06,2.46)* | - |
| Medication (AI vs. Tamoxifen) | 1.91 (1.28, 2.87)** | 1.95 (1.29, 2.94)** | 1.94 (1.29,2.93)** | 1.98 (1.31, 2.98)** | 1.92 (1.28,2.88)** | 2.59 (1.52, 4.40)*** |
| BMI (Overweight vs. Normal) | 1.58 (1.04, 2.43)* | 1.50 (0.98, 2.30) | 1.50 (0.98, 2.29) | 1.43 (0.93, 2.18) | 1.59 (1.03,2.44)* | - |
| Daily sitting time (≤6 hours vs. >6 hours) | 1.83 (1.25, 2.70)** | 1.77 (1.20, 2.62)** | 1.86 (1.27, 2.74)** | 1.78 (1.21,2.63)** | 1.83 (1.24, 2.68)** | 2.01 (1.22,3.32)** |
| Chemotherapy (No vs. Yes) | - | - | - | - | - | 1.62 (0.94, 2.71) |
| Medication Concerns | - | 0.92 (0.86, 0.99)* | - | - | ||
| Goodness-of-Fit (p-value) | 0.59 | 0.09 | 0.40 | 0.88 | 0.57 | 0.39 |
| AIC | 660.80 | 650.93 | 657.88 | 657.88 | 662.63 | 395.52 |
| C-statistic | 0.70 | 0.69 | 0.69 | 0.70 | 0.69 | 0.69 |
Note: Each model controls for race, age, medication and Total Endocrine symptoms or one of the endocrine symptom subscales by default. Stepwise selection was performed in order to determine the inclusion of additional variables.
CI=confidence interval
*
p<0.05;
**
p<0.01;
***
p<0.001