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RACK1 promotes the ubiquitination of p53. (A) Overexpression of RACK1 in NCI-H226 cells promoted the ubiquitination of p53. (B) Overexpression of RACK1 in NCI-H226 and H1703 cells inhibited the p53 and p21 protein levels. (C) Treatment of NCI-H226 and H1703 cells with PD166866 increased the protein levels of p53 and p21. (D) The effects of PD166866 on the interaction between RACK1 and MDM2 were detected by immunoprecipitation.
