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PD166866 and RG7112 cooperatively inhibit the malignancy of lung cancer. (A) PD166866 combined with RG7112 inhibited the colony formation of NCI-H226 and H1703 cells. (B) PD166866 combined with RG7112 promoted the expression of p53 and p21. (C) PD166866 combined with RG7112 inhibited the distal seeding of NCI-H226 cells. The gross morphology of lungs is shown. H&E staining was performed, and the numbers of foci were analyzed (10x). **P < 0.01; ##P < 0.01.
