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Schematic of the proposed mechanism(s) for FGFR/RACK1 interaction with MDM2 to inhibit the senescence of lung squamous cell carcinoma. The interaction of FGFR/RACK1 with MDM2 promotes the degradation of P53 (left); the FGFR inhibitor PD166866 and the MDM2/p53 inhibitor RG7112 cooperatively decrease the interactions between RACK1 and MDM2; weaken the interaction between MDM2/p53; and induce the accumulation of p53 and the upregulation of p21 and consequently cell senescence.
