Table 4.

Adverse events of the phase 1b/2 study

AE	Phase 1b (n = 15)				Phase 2 (n = 113)
	Any grade		Grade ≥ 3		Any grade		Grade ≥ 3
	n	%	n	%	n	%	n	%
Leucopenia	14	93.3	9	60.0	93	82.3	78	69.0
Anemia	11	73.3	4	26.7	93	82.3	42	37.2
Neutropenia	11	73.3	10	66.7	86	76.1	78	69.0
Thrombocytopenia	8	53.3	5	33.3	58	51.3	35	31.0
Nausea/vomiting	6	40.0			72	63.7	5	4.4
Fever	4	26.7	2	13.3	42	37.2	12	10.6
Hypokalemia	4	26.7			34	30.1	17	15.0
Hypocalcaemia	8	53.3	1	6.7	25	22.1	3	2.7
Hypoalbuminemia	4	26.7			32	28.3	2	1.8
Upper respiratory tract infection	4	26.7	1	6.7	20	17.7	3	2.7
Pulmonary infection	1	6.7	1	6.7	15	13.3	7	6.2
Fatigue	3	20.0	1	6.7	12	10.6
Hyponatremia	2	13.3	2	13.3	12	10.6	12	10.6
Hyperglycemia	2	13.3			12	10.6	7	6.2
ALT/AST elevation	2	13.3			8	7.1	3	2.7
BUN elevation	1	6.7			8	7.1	3	2.7
Skin rash	1	6.7			7	6.2
Lower limb edema					7	6.2	2	1.8