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. 2021 Aug 15;18(3):675–692. doi: 10.20892/j.issn.2095-3941.2020.0136

Figure 5.

Figure 5

DPP10-AS1 and DPP10 are coordinately upregulated in lung cancer. (A) Difference in expression levels of DPP10 mRNA between lung cancer tissues and adjacent cancerous tissues. β-actin served as the internal control for normalization. The statistical difference was analyzed with Wilcoxon signed-rank test. (B) The ratio between the relative quantification of DPP10 mRNA expression in lung cancer tissues vs. paired adjacent noncancerous lung tissues for each case. qRT-PCR (C) and Western blot (D) analysis of the relative expression of DPP10 mRNA and protein level in lung cell lines. The correlation between DPP10-AS1 and DPP10 mRNA in lung cancer tissues (E) and cell lines (F). Data were subjected to Pearson correlation analysis. (G, H) According to the expression of DPP10-AS1, the qRT-PCR data from 94 pairs of clinical samples were classified as DPP10-AS1 high and DPP10-AS1 low. The relative expression of DPP10 mRNA and DPP10-AS1 is compared in box plots. (I, J) According to the expression of DPP10, the qRT-PCR data from 94 pairs of clinical samples were classified as DPP10 high and DPP10 low. The relative expression of DPP10-AS1 and DPP10 is compared in box plots. *P < 0.05, **P < 0.01, ****P < 0.0001.