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. 2021 Aug 15;18(3):675–692. doi: 10.20892/j.issn.2095-3941.2020.0136

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Copyright: © 2021, Cancer Biology & Medicine

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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DPP10-AS1 promotes lung cancer cell growth and proliferation through upregulating DPP10 mRNA expression. (A) Rescue effect of DPP10 overexpression on DPP10-AS1 knockdown-mediated cell growth inhibition in SPC-A1 and NCI-H1299 cells, determined with MTT assays. (B) Rescue effect of DPP10 knockdown on DPP10-AS1 overexpression-mediated cell growth promotion, determined with MTT assays. (C) Colony formation assays were performed to investigate the effects of DPP10-AS1 knockdown and DPP10 overexpression on SPC-A1 and NCI-H1299 cell proliferation. (D) The effects of DPP10-AS1 overexpression and DPP10 knockdown on SPC-A1 and NCI-H1299 cell proliferation were detected with colony formation assays. The number of colonies was counted, and statistical analysis is shown at right. (E) Rescue effects of DPP10 overexpression or depletion on DPP10-AS1-mediated DPP10 mRNA expression changes. Data are shown as mean ± SD from 3 independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.