Figure 4.

Therapeutic treatment of experimental mice with developed subcutaneous xenografts of U87 human glioblastoma. (A) Graft growth rates in mice with an average initial tumor size of 15 mm³ (n = 7 per group). (B) Graft growth rates in mice with the average initial tumor size of 92 mm³ (n = 6 per group). The median ± standard error of the mean are given; confidence was estimated using the Mann–Whitney criterion in the Statistica 10 software package, *P < 0.05. (C) Treated animals. (D) Animals from the CP + DNAmix group with a characteristic symptom complex manifestation: 1) animal with severe anorexia; 2) animal with hind limb paralysis (indicated by the arrow).